Chicago Center for Systems Biology
The Chicago Center for Systems Biology (CCSB) is one of thirteen National Centers for Systems Biology funded by the National Institute of General Medical Sciences (NIGMS). The Center is located at the University of Chicago and represents a multi-disciplinary collaboration with Northwestern University investigators at the Evanston and Chicago campuses, fostered by the Chicago Biomedical Consortium (CBC), with support from The Searle Funds at The Chicago Community Trust. To answer its central questions, the Center’s investigators are using model organisms such as worms and fruit flies to identify ancient stress-response circuits and learn how these have evolved differently in each system. Other topics involving fruit flies examine the genetic networks that maintain both stability and flexibility for repeating anatomical patterns during development, and how gene transcription guides the decisions each cell must make as it chooses to become one of two cell types within a fly’s eye.